个人简介

国家杰出青年基金获得者；国家海外高层次青年人才；广东省“珠江人才计划”引进创新创业团队带头人。

2002年毕业于北京师范大学获理学学士学位，2005年毕业于中国协和医科大学获医学硕士学位，2009年毕业于北京生命科学研究所获理学博士学位。后在美国西奈山医学院（Icahn School of Medicine at Mount Sinai, NY, U.S.A.）进行博士后研究至2015年底。

研究工作主要集中在胚胎干细胞、体细胞重编程和早期胚胎发育的相分离、表观遗传和染色质高级结构的调控机制，以及利用iPS细胞建立肿瘤疾病模型等生物医学领域。已在国际著名期刊以通讯或第一作者发表论文13篇（IF>20的8篇），包括Nature、Nature Genetics、Cell Stem Cell（两篇）、Cell Research（两篇）、Nature Structural & Molecular Biology等，其中相分离的研究成果被Nature Structural & Molecular Biology杂志评为2021年年度关键进展。

研究领域

本课题组通过深入研究干细胞的多能性以及体细胞重编程的分子机理，并通过建立单细胞多组学技术阐明早期胚胎发育的调控机制，同时利用iPS细胞建立肿瘤疾病模型，对于干细胞的临床应用具有重要意义。基于此，实验室正在开展以下几个方面研究：
1.    利用基因编辑和蛋白质组学等手段研究多能干细胞、体细胞重编程以及早期胚胎发育的表观遗传调控机制，特别是相分离的调控机制和功能；
2.    开发新型单细胞多组学技术（CARE-seq、Couple-seq等），并结合染色体三维结构技术（HiC、HiChIP）等研究干细胞命运转变及早期胚胎发育的表观机制；
3.    建立生物信息学、人工智能（机器学习等）等相关算法进行表观组学研究，整合二维的基因组学、转录组学、蛋白组学等数据和HiC、HiChIP等染色质三维数据，进行细胞命运和疾病发生的研究；
4.    利用类器官技术和诱导多能干细胞（iPS细胞）建立了世界上首个乳腺癌模型，是迄今唯一能追踪肿瘤起源细胞和起源机制的系统，进一步利用该模型研究肿瘤发病机理、筛选预防及治疗药物等。

近5年发表的学术论文

代表性通讯及第一作者论文（含共同）：

  1. Xiuxiao Tang*, Ranran Dai*, Li Qing*, Zhida Zhang*, Hongmei Li, Lizi Lu, Hancheng Lin, Danling Ji, Wei Dan, Yuqi He, Xinyi Liu, Tao Yang, Wakam Chang, Yang Mao#, Shisheng Sun#, Junjun Ding# (Corresponding author). Nuclear polysaccharides maintain H3K9me3-heterochromatin and genomic stability. Nature cell biology. 2026. Accepted. (IF:24.2)
  2. Shaoshuai Jiang*, Xinyi Liu*, Zhuheng Zhang*, Mingzhu Yang*, Xing Zhu, Lin Ma, Longying Zhao, Xiaoru Ling, Ziqiang Zhou, Ziqiang Wu, Jiale Qu, Haochen Li, Jiawei Liang, Zhiheng Deng, Qi Tian, Xiaona Huang, Xianglin Huang, Jin Tan, Jun Sun, Diana Guallar, Partha Pratim Das, Luca Pinello, Liang Wang, Hongfu Wu, Dong-feng Huang, Jichang Wang, Hancheng Lin, Jin Bai#, Lili Fan#, Wei Chi#, Xue Xiao#, Junjun Ding# (Corresponding author). Catalytic-independent regulation of enhancer-promoter interactions by biocondensates of histone demethylase JMJD2/KDM4 for cell fate transition. Nature Genetics. 2025. Accepted. (IF:37.4)
  3. Jingxin Liu*, Cai Zhao*, Jiahao Chen*, Pengguihang Zeng*, Qingjian Li, Ranran Dai, Xingqiang Lai, Wenqian Song, Jianing Chen, Xixi Zhu, Xinyi Liu, Jun Sun, Jia Wang, Peihang Fang, Tengfei Wang, Wenjie Chen, Diana Guallar, Nan Cao, Jianli Zhao, Shicheng Su, Andy Peng Xiang, Yi Arial Zeng, Jie Li, Junchao Cai, Dung-Fang Lee, Jinxin Bei, Yongliang Huo, Hai Hu, Shengbao Suo#, Dong-Feng Huang#, Jin Bai#, Junjun Ding# (Corresponding author). Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by BRCA1 mutation. Science Advances. 2025 Jul 25;11(30):eadi2370. doi: 10.1126/sciadv.adi2370. (IF:12.5)
  4. Wei Jin*, Shaoshuai Jiang*, Xinyi Liu*, Yi He*, Tuo Li, Jingchun Ma, Zhihong Chen, Xiaomei Lu, Xinguang Liu, Weinian Shou, Guoxiang Jin, Junjun Ding# (Corresponding author), Zhongjun Zhou#. Disorganized chromatin hierarchy and stem cell aging in a male patient of atypical laminopathy-based progeria mandibuloacral dysplasia type A. Nature Communications. 2024 Nov 20;15(1):10046. doi: 10.1038/s41467-024-54338-3. (IF:16.6)
  5. Xiuxiao Tang*, Pengguihang Zeng*, Kezhi Liu, Li Qing, Yifei Sun, Xinyi Liu, Lizi Lu, Chao Wei, Jia Wang, Shaoshuai Jiang, Jun Sun, Wakam Chang, Haopeng Yu, Hebing Chen, Jiaguo Zhou, Chengfang Xu#, Lili Fan#, Yi-Liang Miao#, Junjun Ding# (Corresponding author). The PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation. Nature Communications. 2024 Apr 1;15(1):2813. doi: 10.1038/s41467-024-47048-3. (IF:16.6)
  6. Jun Sun*, Jiale Qu*, Cai Zhao*, Xinyao Zhang, Xinyu Liu, Jia Wang, Chao Wei, Xinyi Liu, Mulan Wang, Pengguihang Zeng, Xiuxiao Tang, Xiaoru Ling, Li Qing, Shaoshuai Jiang, Jiahao Chen, Tara SR Chen, Yalan Kuang, Jinhang Gao, Xiaoxi Zeng, Dongfeng Huang, Yong Yuan#, Lili Fan#, Haopeng Yu#, Junjun Ding# (Corresponding author). Precise prediction of phase-separation key residues by machine learning. Nature Communications. 2024 Mar 26;15(1):2662. doi: 10.1038/s41467-024-46901-9.(IF:16.6)
  7. Jiale Qu*, Jun Sun*, Cai Zhao, Xinyi Liu, Xinyao Zhang, Shaoshuai Jiang, Chao Wei, Haopeng Yu, Xiaoxi Zeng#, Lili Fan#, Junjun Ding# (Corresponding author). Simultaneous profiling of chromatin architecture and transcription in single cells. Nature Structural & Molecular Biology. 2023 Sep;30(9):1393-1402. doi: 10.1038/s41594-023-01066-9.(IF:18.36)
  8. Chao Wei*, Lumeng Jia*, Xiaona Huang*, Jin Tan*, Mulan Wang, Jing Niu, Yingping Hou, Jun Sun, Pengguihang Zeng, Jia Wang, Li Qing, Lin Ma, Xinyi Liu, Xiuxiao Tang, Fenjie Li, Shaoshuai Jiang, Jingxin Liu, Tingting Li, Lili Fan, Yujie Sun, Juntao Gao, Cheng Li, Junjun Ding# (Corresponding author). CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation. Cell Research. 2022 Aug;32(8):744-760. doi: 10.1038/s41422-022-00676-0. (IF:46.297)
  9. Xinyi Liu*, Shaoshuai Jiang*, Lin Ma, Jiale Qu, Longying Zhao, Xing Zhu, Junjun Ding# (Corresponding author). Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization. Genome Biology. 2021 Aug 17;22(1):230. doi: 10.1186/s13059-021-02455-3. (IF: 17.906)
  10. Jia Wang, Haopeng Yu, Qian Ma, Pengguihang Zeng, Danya Wu, Yingping Hou, Xinyi Liu, Lumeng Jia, Jun Sun, Yilong Chen, Diana Guallar, Miguel Fidalgo, Jiahao Chen, Yangyinhui Yu, Shaoshuai Jiang, Fenjie Li, Cai Zhao, Xianglin Huang, Jianlong Wang, Cheng Li, Yujie Sun, Xiaoxi Zeng, Wei Zhang, Yiliang Miao, Junjun Ding# (Corresponding author). Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions. Cell Stem Cell. 2021 May 25; doi:https://doi.org/10.1016/j.stem.2021.04.023. (IF: 25.269)

受邀评论与综述

  1. Pengguihang Zeng*, Zhuheng Zhang*, Xinyi Liu, Junjun Ding# (Corresponding author). iPSC-Derived Breast Cancer Models: Advancing the Study of BRCA1-Driven Tumorigenesis. Life Medicine. 2025. Accepted. (IF: 6.0)
  2. Xinyi Liu, Junjun Ding# (Corresponding author). Breaking a chromatin domain boundary by deleting a single CTCF motif impacts development. Developmental Cell. 2025 Jul 7;60(13):1811-1813. (IF: 8.7)
  3. Xinyi Liu, Xiaoru Ling, Qi Tian, Zibin Huang, Junjun Ding# (Corresponding author). Nuclear remodeling during cell fate transitions. Current Opinion in Genetics & Development. 2025 Feb;90:102287. (IF: 4.75)
  4. Lili Fan*, Xinyi Liu*, Diana Guallar, Junjun Ding# (Corresponding author). Chromatin 3D structure, phase separation and disease.Life Medicine. 2023 Mar 8;2(2):lnad010. (IF: 6.0)
  5. Xiaoru Ling*, Xinyi Liu*, Shaoshuai Jiang, Lili Fan, Junjun Ding# (Corresponding author). The dynamics of three-dimensional chromatin organization and phase separation in cell fate transitions and diseases. Cell Regeneration. 2022 Dec 21;11(1):42. (IF: 3.6)

获奖荣誉

  1. 2024年 国家杰出青年基金
  2. 2017年 广东省“珠江人才计划”引进创新创业团队（带头人）
  3. 2017年 干细胞年会青年论坛一等奖（仅一名）
  4. 2016年 中组部国家海外高层次人才计划（青年项目）
  5. 2015年 william威廉英国百人计划