个人简介
Williamhill中文教授，博士生导师。2003年7月毕业于南开大学生物科学系，2009年5月中国科学院上海生物化学与细胞生物学研究所活鹅博士学位，此后分别于美国加州大学圣地亚哥分校和美国加州大学欧文分校进行博士后研究。2015年回国，就职于Williamhill中文。
学术成果
主要学术研究成果与贡献
（1）首次发现U4/U6/U2 snRNP具有类似U1抑制pre-mRNA PCPA (premature cleavage and polyadenylation)和PTT(premature transcription termination)的功能，从而在共转录加工的分子机制领域提出普适性模型：pre-mRNA splicing在转录组规模可防止PCPA/PTT，从而正调控transcription。相关结果以最后通讯作者发表在国际权威期刊《PNAS》2024和《Cell Reports》2025上，并应邀在遗传学领域综述顶刊《Trends in Genetics》2025发表Forum article，正式提出splicing inhibits PCPA and PTT这一概念。
（2）2023年在生化领域权威期刊《JBC》上以最后通讯作者发表U1 snRNP telescripting的分子机制论文，为U1抑制pre-mRNA PCPA与PTT带来最新的见解。
（3）2017年在国际知名刊物《NAR》以最后通讯作者发表snoRNA概念与功能突破性进展研究，Article被评为NAR Breakthrough Article.首次揭示snoRNA可能在真核生物mRNA3'末端加工中发挥功能。
近5年发表的学术论文
1.Sheng Yang, Mengzhao Li, Chengguo Yao* (2025) Splicing inhibits premature cleavage and polyadenylation. Trends in Genetics (In press).
2.Qiumin Feng, Zejin Lin, Danhui Zhao, Mengzhao Li, Sheng Yang, Andy Peng Xiang, Congting Ye*, Chengguo Yao* (2025) Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs. Cell Reports. Mar 25.
3.Qiumin Feng, Danhui Zhao, Zejin Lin, Mengzhao Li, Andy Peng Xiang, Congting Ye*, Chengguo Yao* (2024) U4 snRNP inhibits premature cleavage and polyadenylation of pre-mRNAs.PNAS. June 25.
4.Qiumin Feng, Zejin Lin, Yanhui Deng, Yi Ran, Rui Yu, Andy Peng Xiang, Congting Ye*, Chengguo Yao* (2023) The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs. JBC. Available online 22 May 2023, 104854.
5.Ran, Yi; Huang, Shanshan; Shi,Junjie; Feng, Qiumin; Deng,Yanhui; Xiang AP; Yao, Chengguo* (2022) CFIm25 regulates human stem cell function independently of its role in mRNA alternative polyadenylation. RNA Biology 19(1):686-702.
6.Yixian Cun, Sanqi An, Haiqing Zheng, Jing Lan, Wenfang Chen, Wanjun Luo, Chengguo Yao, Xincheng Li, Xiang Huang, Xiang Sun, Zehong Wu, Yameng Hu, Ziwen Li, Shuxia Zhang, Geyan Wu, Meisongzhu Yang, Miaoling Tang, Ruyuan Yu, Xinyi Liao, Guicheng Gao, Wei Zhao, Jinkai Wang, Jun Li (2021）Specific Regulation of m 6 A by SRSF7 Promotes the Progression of Glioblastoma. Genomics Proteomics Bioinformatics . S1672-0229(21)00252-7.
7.Ran, Yi; Deng, Yanhui; Chengguo Yao*(2021) U1 snRNP telescripting: molecular mechanisms and beyond. RNA Biology 18(11):1512-1523.