个人简介

现任Williamhill中文副教授，博士生导师。主要研究方向为病毒感染与免疫分子机制、抗病毒与抗炎症药物研究。主持国家自然科学基金项目3项，广东省自然科学基金1项；作为课题骨干参与“艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项、教育部科学技术研究重大项目等研究工作。近年来以第一作者、通讯作者（含共同）分别在Proc Natl Acad Sci USA、Journal of Virology、Journal of Infectious Diseases、Journal of Infection、PLOS Neglected Tropical Diseases等杂志发表多篇论著。

研究领域：课题组聚焦病毒-宿主相互作用机制研究，以登革病毒、寨卡病毒等蚊媒病毒为主要研究对象。围绕病毒入侵、复制与致病等核心环节，结合高通量基因功能筛选与多组学分析技术，依托细胞与动物模型并结合临床样本，运用病毒学、细胞生物学及分子生物学等手段，系统鉴定病毒感染的关键宿主依赖因子与病毒组分，深入解析病毒与宿主免疫系统互作诱发重症疾病的分子机制。在此基础上，挖掘病毒性重症的早期诊断与预测分子标志物，并针对关键靶分子开展抗病毒、抗炎药物筛选及治疗策略研究。

学术成果

代表性学术论著

1. Zhang, S., Chen, D., Zhang, K., Liu, M., Liang, H., Liang, L., Liang, J., Liang, M., An, S., Lyu, M., Zhu, J., Li, S., Hu, D., Zhu, X., Wu, J., He, Z. *, & Li, M*. ZIKV infection causes placental inflammation through activating PANoptosis. Journal of virology. 2025, 99(12), e0175925. 
2. Li, Y., Liu, M., Liang, J., Ye, H., Lyu, M., Chen, D., Liang, L., Zhang, S., Zhang, K., An, S., Zhou, W., Wu, J., Zhu, X.*, & He, Z.*. Epidemiological and molecular characteristics of human parainfluenza virus in southern China during 2016-2020. Virologica Sinica. 2025, 40(2), 157–165.
3. Tan Y., Ren W., Zhou W., Qin X., Lei G., Zhou W., Liu B., Li Y., Hou Y., Kang J., Li X., Hong Y., He Z.*, Wei G.*, Zhu X*. C19orf66 restricts Coxsackievirus B infection by inducing lysosomal degradation of the viral proteins 3Dpol and 2Apro and exhibits neuroprotective effects in CVB-challenged mice. International immunopharmacology.2025, 151, 114343. 
4. Zhang K, Liang J, Zhang B, Huang L, Yu J, Xiao X, He Z*, Tao H*, Yuan J*. A Marine Natural Product, Harzianopyridone, as an Anti-ZIKV Agent by Targeting RNA-Dependent RNA Polymerase. Molecules. 2024 Feb 23;29(5):978. 
5. Ye H, Zhang S, Zhang K, Li Y, Chen D, Tan Y, Liang L, Liu M, Liang J, An S, Wu J, Zhu X, Li M, He Z*. Epidemiology, genetic characteristics, and association with meteorological factors of human metapneumovirus infection in children in southern China: A 10-year retrospective study. International Journal of Infectious Diseases. 2023 Dec;137:40-47. 
6. Zhu Y, Yu J, Chen T, Liu W, Huang Y, Li J, Zhang B, Zhu G, He Z*, Long Y*, Yuan J*. Design, synthesis, and biological evaluation of a series of new anthraquinone derivatives as anti-ZIKV agents. European Journal of Medicinal Chemistry. 2023 Oct 5;258:115620. 
7. Liang M, Li Y, Zhang K, Zhu Y, Liang J, Liu M, Zhang S, Chen D, Liang H, Liang L, An S*, Zhu X*, He Z*. Host factor DUSP5 potently inhibits dengue virus infection by modulating cytoskeleton rearrangement.Antiviral Research. 2023 Jul;215:105622. 
8. Wu Y, Chen D, Hu Y, Zhang S, Dong X, Liang H, Liang M, Zhu Y, Tan C, An S, Zhu X, Yuan J, Li M, He Z*. Ring Finger Protein 215 Negatively Regulates Type I IFN Production via Blocking NF-κB p65 Activation. Journal of Immunology. 2022 Nov 15;209(10):2012-2021. 
9. He Z#, An S#, Chen J, Zhang S, Tan C, Yu J, Ye H, Wu Y, Yuan J, Wu J, Zhu X*, Li M*. Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target. Proc Natl Acad Sci USA. 2020 Sep 22;117(38):23869-23878. 
10. Wu Y, Yang X, Yao Z, Dong X, Zhang D, Hu Y, Zhang S, Lin J, Chen J, An S, Ye H, Zhang S, Qiu Z, He Z*, Huang M*, Wei G*, Zhu X*. C19orf66 interrupts Zika virus replication by inducing lysosomal degradation of viral NS3. PLoS Negl Trop Dis. 2020 Mar 9;14(3):e0008083. 
11. Hu Y#, Dong X#, He Z#, Wu Y, Zhang S, Lin J, Yang Y, Chen J, An S, Yin Y, Shen Z, Zeng G, Tian H, Cai J, Yang Y, Guan H, Wu J, Li M, Zhu X. Zika virus antagonizes interferon response in patients and disrupts RIG-I-MAVS interaction through its CARD-TM domains. Cell & Bioscience. 2019 Jun 7;9:46. 
12. He Z#, Chen J#, Zhu X, An S, Dong X, Yu J, Zhang S, Wu Y, Li G, Zhang Y, Wu J, Li M. NLRP3 Inflammasome Activation Mediates Zika Virus-Associated Inflammation. Journal of Infectious Diseases. 2018 May 25;217(12):1942-1951.
13. He Z#, Zhu X#, Wen W#, Yuan J, Hu Y, Chen J, An S, Dong X, Lin C, Yu J, Wu J, Yang Y, Cai J, Li J, Li M. Dengue Virus Subverts Host Innate Immunity by Targeting Adaptor Protein MAVS. Journal of Virology. 2016 Jul 27;90(16):7219-7230. 
14. Wen W#, He Z#, Jing Q#, Hu Y, Lin C, Zhou R, Wang X, Su Y, Yuan J, Chen Z, Yuan J, Wu J, Li J, Zhu X, Li M. Cellular microRNA-miR-548g-3p modulates the replication of dengue virus.Journal of Infection. 2015 Jun;70(6):631-640. （#并列第一作者）
15. Zhu X#, He Z#, Yuan J#, Wen W, Huang X, Hu Y, Lin C, Pan J, Li R, Deng H, Liao S, Zhou R, Wu J, Li J, Li M. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cellular Microbiology. 2015 Jan;17(1):105-118. 
16. Zhu X#, He Z#, Hu Y#, Wen W, Lin C, Yu J, Pan J, Li R, Deng H, Liao S, Yuan J, Wu J, Li J, Li M. MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. PLoS Negl Trop Dis. 2014 Aug 14;8(8):e3088.