个人简介/Brief introduction

Williamhill中文教授、博士生导师，国家级人才工程青年项目入选者，广东省青年珠江学者、william威廉英国引进青年杰出人才。2016年毕业于瑞士联邦理工大学（EPFL），师从代谢领域权威Johan Auwerx 教授获得博士学位，2017年william威廉英国“百人计划”项目引进。团队研究通过单细胞多组学技术结合分子细胞生物学、模式动物和临床样本研究个体衰老的基本调节机制，并以发育为借鉴，寻求提高衰老组织再生能力的新策略。前期研究构建了首个人类肢体发育和骨骼肌衰老的单细胞图谱；揭示了线粒体对维持干细胞功能的重要作用，提出线粒体代谢失衡是导致干细胞衰老的重要原因。相关成果发表于Nature、Science、Nature Aging、Science Translational Medicine等期刊，并受邀为Nature Reviews Endocrinology、Science Bulletin等撰写综述，获授权国际/国内发明专利3项，软件著作权3项。

      现阶段主要研究方向如下：
1. 成体干细胞衰老的分子机制。干细胞长期被认为具备永生能力，近年的研究发现其会随着个体衰老而衰老，但调节干细胞衰老的分子机制不明。团队以骨骼肌干细胞为模型，研究静息干细胞在正常生理条件下的衰老机制，揭示细胞内源性信号通路的变化、线粒体功能改变、细胞微环境扰动对干细胞，尤其是骨骼肌干细胞衰老的影响，以寻找到延缓干细胞衰老、延长寿命、促进老年健康的有效方法。

2. 发育过程中的细胞命运决定。发育的本质是细胞在特定时空精确分化的过程，是研究细胞命运决定的理想模型。团队以肢体发育为重点，借助自主开发的单细胞数据分析工具，并结合体内外基因功能验证方法，系统性研究发育过程中细胞命运的歧化过程和和空间位置的确定机制，最终目的在于为组织高质量再生提供方法和技术指引。

 3. 能量代谢和表观遗传对成体干细胞功能的影响。线粒体能量代谢与蛋白质表观遗传修饰存在密切联系，若干代谢物如NAD+、乙酰辅酶A等可以直接作为蛋白质乙酰化、甲基化等修饰的底物。团队关注乙酰化转移酶、去乙酰化酶等对骨骼肌干细胞活化、分化、衰老等细胞功能和行为的影响，为促进骨骼肌再生，防治肌萎缩和肌肉营养不良等疾病提供借鉴。

近5年发表的学术论文/Publications

第一或通讯作者论文/fist or corresponding author papers

*, corresponding authors; #, equal contribution

  1. Zhang B#, He P#, Lawrence J#, Wang S#, Tuck E, Williams B, Roberts K, Kleshchevnikov V, Mamanova L, Bolt L, Polanski K, Li T, Elmentaite R, Fasouli E, Prete M, He X, Yayon N, Fu Y, Yang H, Liang C, Zhang H, Blain R, Chedotal A, FitzPatrick D, Firth H, Dean A, Bayraktar O, Marioni J, Barker R, Storer M, Wold B, Zhang H* & Teichmann S* . A human embryonic limb cell atlas resolved in space and time. Nature, 2024 (IF: 48.5).
  2. Kedlian V#, Wang Y#, Liu T#, Chen X, Bolt L, Tudor C, Shen Z, Fasouli E, Prigmore E, Kleshchevnikov V, Pett J, Li T, Lawrence J, Perera S, Prete M, Huang N, Guo Q, Zeng X, Yang L, Polanski K, Chipampe N, Dabrowska M, Li X, Bayraktar O, Patel M, Kumasaka N, Mahbubani K, Xiang A, Meyer K, Saeb-Parsy K*, Teichmann S* & Zhang H*. Human skeletal muscle aging atlas. Nat Aging, 2024 (IF: 19.4, ESI高被引).
  3. Zhang B. & Zhang H*. The human limb cell atlas: charting uncharted territories and setting sail on the new voyage of limb development research. Sci Bull, 2025 (IF: 21.1).
  4. Guo F#, Zhang B#, Yang H#, Fu Y, Wang Y, Huang J, Cheng M, Li X, Shen Z, Li L, He P, Xiang P, Wang S* & Zhang H*. Systemic transcriptome comparison between early- And late-onset pre-eclampsia shows distinct pathology and novel biomarkers. Cell Prolif, 2021 (IF: 5.6).
  5. Peng B, Wang Y & Zhang H*. Mitonuclear Communication in Stem Cell Function. Cell Prolif, 2024 (IF: 5.6).
  6. Aging Biomarker C#, Huang N#, …, Zhang H*, Zhang W*, Liu G*, Pei G*, Liu Y*, Zhu D*, Dong B*. A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium. Life Med, 2024 (IF: 6.0).
  7. Aging Biomarker C#, Bao H#, Cao J#, Chen M#, Chen M#, Chen W#, Chen X#, Chen Y#, …, Zhang H*,…, Pei G* & Liu GH*. Biomarkers of aging. Sci China Life Sci, 2023 (IF: 9.5, ESI高被引, 封面论文). 
  8. Chen Y#, Zhang B#, Liu T, Chen X, Wang Y* & Zhang H*. T Cells With Activated STAT4 Drive the High-Risk Rejection State to Renal Allograft Failure After Kidney Transplantation. Front Immunol, 2022 (IF: 5.9).
  9. Yang H#, Guo F#, Guo Q, Wang Y, He P, Zhang H* & Wang S*. The clinical value of PlGF and the sFlt1/PlGF ratio in the management of hypertensive pregnancy disorders: A retrospective real-world study in China. Clin Chim Acta, 2022 (IF: 2.9).
  10. Peng B, Chen Y, Wang Y, Fu Y, Zeng X, Zhou H, Abulaiti Z, Wang S & Zhang H*. BTG2 acts as an inducer of muscle stem cell senescence. Biochem Biophys Res Commun, 2023 (IF: 2.2).

其他论文/other publications

  1. Ning Y, Duo S, Lin X, Zhang H, Fei J, Zhang B, Zeng Y, Xie, D, Chen J, Liu X. & Han C. Transcription factor PBX4 regulates limb development and haematopoiesis in mice. Cell Prolif, 2024 (IF: 5.6).
  2. Li G, Huang L, Zhang B, Liu S, Liang J, Ding Y, Zeng X, Lai B, Ma Y, Wang Y, Wang R, Zhang H, Zeng Y. The LINGO-1-deficient neural stem cell-derived neural tissueoid showed enhanced retention and neuronal relay in the transected spinal cord. Chem Eng J, 2024 (IF: 13.2).
  3. Ren J, Song M, Zhang W, Cai J, Cao, F, Cao Z, …, Zhang H, Zhang L, Zhang X, Zhang Y, Zhang Y, Zhang Z, Zhao T, Zhao Y, ZHou Z, Zhu D, Zou W, Pei G, Liu G. The Aging Biomarker Consortium represents a new era for aging research in China. Nat Med, 2023 (IF: 50.0).
  4. Liu T, Chen X, Peng B, Liang C, Zhang H & Wang S. A novel prognostic model based on immunogenic cell death-related genes for improved risk stratification in hepatocellular carcinoma patients. J Cancer Res Clin Oncol, 2023 (IF: 2.8).
  5. Lai B, Wu R, Han W, Bai Y, Liu J, Yu H, Yang S, Wang L, Ren J, Ding Y, Li G, Zeng X, Ma Y, Quan Q, Xing L, Jiang B, Wang Y, Zhang L, Chen Z, Zhang H, Chen Y, Zheng Q & Zeng Y*. Tail nerve electrical stimulation promoted the efficiency of transplanted spinal cord-like tissue as a neuronal relay to repair the motor function of rats with transected spinal cord injury. Biomaterials, 2023 (IF: 12.9).
  6. Lai B, Bai Y, Han W, Zhang B, Liu S, Sun J, Liu J, Li G, Zeng X, Ding Y, Ma Y, Zhang L, Chen Z, Wang J, Xiong Y, Wu J, Quan Q, Xing L, Zhang H & Zeng Y*. Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair. Bioact Mater, 2022 (IF: 20.3).
  7. Romani M, Sorrentino V, Oh C, Li H, de Lima T, Zhang H, Shong M & Auwerx J. NAD(+) boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell reports, 2021 (IF: 6.9).
  8. Muus C, Luecken M, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav E, …, Consortium NL & Human Cell Atlas Lung Biological N. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med, 2021 (IF: 50.0, ESI高被引).
  9. Li G, Zhang B, Sun J, Shi L, Huang M, Huang L, Lin Z, Lin Q, Lai B, Ma Y, Jiang B, Ding Y, Zhang H, Li M, Zhu P, Wang Y, Zeng X & Zeng Y. An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury. Bioact Mater, 2021 (IF: 20.3).

专利和软著/Patents and Software Copyrights

1   Zhang, H., Menzies, K. J., Auwerx, J. Ryu, D. Agents and methods using thereof for the prevention and treatment of stem cells senescence. 已授权PTC专利, WO2017042198, (2017). 
2   Zhang, H., Menzies, K. J., Auwerx, J. Ryu, D. Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders. 已授权PTC专利, WO2017042196, (2017).
3  张宏波，王帅玉，张宝，杨浩. 胎盘相关疾病标志物的筛选方法及标志物. 已授权中国发明专利, ZL 2020 1 0908665.8, (2023).
4  张宏波，张宝，王帅玉. 基因拟时序表达分析Python包软件[简称：PLOGS软件]. 已授权软件著作权，5091728，(2020).
5  张宏波，孙萌. 生物学中HE与荧光图配准软件(RBMIC) [简称:RBMIC]. 已授权软件著作权， 14171926，(2024).
6  张宏波，孙萌. 生物学中针对罕见细胞类型的聚类可视化软件(RCI-SCORE) [简称:RCI-SCORE]. 已授权软件著作权， 14171935，(2024).