个人简介
william威廉英国副教授；2015年毕业于Williamhill中文，获临床医学学士学位；2020年毕业于william威廉英国附属第一医院，获外科学博士学位；此后在Williamhill中文开展博士后及特聘副研究员工作，2024年转聘副教授。
以通讯或第一作者（共同）在Nat Cell Biol、Nat Commun、Cell Rep Med、Cell Rep、Adv Sci、eLife、Cell Discov、Hum Reprod等刊物发表论文20篇；参与制定临床诊疗专家共识2项；中国发明专利7项，已授权2项，申请国际PCT专利1项；主持国家自然科学基金（联合重点、面上、青年）、中国博士后基金、广东省自然基金等项目。
学术成果
（# co-first author; *co-corresponding author）
- Xia K#, Zhang S#, Peng H#, Chen H#, Yang C, Yu J, Luo P, Lu Q, Chen H, Huang L, Xiong Y, Zhao L, Jia L, Li L, Qiu Y, Guo Y, Liu C, Fan H, Dai Z, Liu G, Ke Q, Wang T, Li W, Chen L*, Deng C*, Xiao H*, Xiang AP*.An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis. Nature Cell Biology. in press
- Liu C#, Peng H#, Yu J#, Luo P#, Xiong C, Chen H, Fan H, Ma Y, Ou W, Zhang S, Yang C, Zhao L, Zhang Y, Guo X, Ke Q, Wang T, Deng C, Li W, Xiang AP*, Xia K*. Impaired ketogenesis in Leydig Cells drives testicular aging. Nature Communications. 2025 Highlighted in Nature Reviews Urology https://www.nature.com/articles/s41585-025-01060-4
- Xia K#, Wang F#, Lai X#, Dong L#, Luo P, Zhang S, Yang C, Chen H, Ma Y, Huang W, Ou W, Li Y, Feng X, Yang B, Liu C, Lei Z, Tu X, Ke Q, Mao FF, Deng C*, Xiang AP*. AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure. Cell Reports Medicine. 2022.
- Yu J#, Yang C#, Guo Y#, Dai Z#, Luo P, Zhang Y, Peng H, Zhang S, Liu C, Zhao L, Fan H, Xiong Y, Xie Q, Jia L, Yu X, Wang T, Li W, Ke Q, Zheng F, Deng C*, Xiang AP*, Chen H*, Xia K*. Tracing the origin of testosterone-producing Leydig cells during postnatal development and regeneration. Cell Reports. 2025
- Xia K#, Wang F#, Tan Z#, Zhang S#, Lai X, Ou W, Yang C, Chen H, Peng H, Luo P, Hu A, Tu X, Wang T, Ke Q, Deng C*, Xiang AP*. Precise correction of Lhcgr mutation in stem Leydig cells by prime editing rescues hereditary primary hypogonadism in mice. Advanced Science. 2023
- Zhang S#, Yang B#, Shen X#, Chen H#, Wang F, Tan Z, Ou W, Yang C, Liu C, Peng H, Luo P, Lei Z, Yan S, Wang T, Ke Q, Deng C, Xiang AP*, Xia K*. AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure. Cell Proliferation. 2024
- Xia K#, Chen H#, Wang J#, Feng X#, Gao Y, Wang Y, Deng R, Wu C, Luo P, Zhang M, Wang C, Zhang Y, Zhang Y, Liu G, Tu X, Sun X, Li W, Ke Q*, Deng C*, Xiang AP*.Restorative functions of autologous stem Leydig cell transplantation in a testosterone-deficient non-human primate model. Theranostics. 2020
- Chen H#, Xia K#, Huang W#, Li H, Wang C, Ma Y, Chen J, Luo P, Zheng S, Wang J, Wang Y, Dong L, Tan Z, Lai X, Mao FF, Li W, Liang X, Wang T, Xiang AP, Qiong K*.Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates. Cell Discovery. 2021
- Xia K#, Luo P#, Yu J#, He S#, Dong L, Gao F, Chen X, Ye Y, Gao Y, Ma Y, Yang C, Zhang Y, Yang Q, Han D, Feng X, Wan Z, Cai H, Ke Q, Wang T, Li W, Tu X, Sun X, Deng C*, Xiang AP*. Single-cell RNA Sequencing Reveals Transcriptomic Landscape and Potential Targets for Human Testicular Ageing. Human Reproduction.2024
- Xia K, Ma Y, Feng X, Deng R, Ke Q, Xiang AP*, Deng C*. Endosialin defines human stem Leydig cells with regenerative potential. Human Reproduction. 2020
- Huang X#, Xia K#, Yang M#, Hong M, Jiang M, Li W, Lei Z, Xiang AP*, Zhao W*. A single-cell atlas of the testicular interstitium defines Leydig progenitor networks sustaining Leydig cell homeostasis across the lifespan. eLife. 2025