个人简介

研究简介

近年聚焦于代谢酶的脑损伤作用及其分子机制研究，发现糖酵解关键酶己糖激酶2（HK2）促进急性缺血性脑卒中等脑损伤过程，揭示其介导炎症、促进外泌体生成等非代谢作用机制，为神经保护药物研发提供全新靶点。此外，完成1.1类急性缺血性脑卒中新药YC-6（已进入Ⅲ期临床试验）的临床前药效学评价，阐明其抗氧化、抗炎等作用机制，并探索YC-6及其同系物在急性高原性脑损伤、出血性脑卒中、重症肺炎等其他适应症的潜在应用。

学术成果

1. Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan*, Xuefeng Hua*, Wei Yin*,Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury. Advanced Science, 2025 Oct;12(39):e01894. 
2. CaiLv Wei, Chen Chen, ShengLong Li, YuXuan Ding, YuWei Zhou, FangYing Mai, ShiRan Hong, JiaXin Wu, Yang Yang, Zhu Zhu, DongDong Xue, XinPeng Ning, LongXiang Sheng, BingZheng Lu, Wei Cai, MingJun Yuan, HuaFeng Liang, SuiZhen Lin, GuangMei Yan, YuPin Chen, YiJun Huang*, Cheng Hu*, Wei Yin*, TRIOL attenuates intracerebral hemorrhage injury by bidirectionally modulating microglia- and neuron-mediated hematoma clearance, Redox Biology. 2025 Mar;80:103487
3. Xincheng Liu, Cui Guo, Tiandong Leng, Zhen Fan, Jialuo Mai, Jiehong Chen, Jinhai Xu, Qianyi Li, Bin Jiang, Ke Sai, Wenzhuo Yang, Jiayu Gu, Jingyi Wang, Shuxin Sun, Zhijie Chen, Yingqian Zhong, Xuanming Liang, Chaoxin Chen, Jing Cai, Yuan Lin, Jiankai Liang, Jun Hu, Guangmei Yan, Wenbo Zhu* and Wei Yin* , Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell.  Cell Death and Disease,  2023, 14(2):142.  
4. Chen Chen, YuWei Zhou, XinPeng Ning, ShengLong Li, DongDong Xue, CaiLv Wei, Zhu Zhu, LongXiang Sheng, BingZheng Lu, Yuan Li, XiaoYuan Ye, YunZhao Fu, Chuan Bai, Wei Cai, YuXuan Ding, SuiZhen Lin, GuangMei Yan, YiJun Huang*, Wei Yin*，Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases，Journal of Neuroinflammation， 2022，19(1)：315.
5. DongDong Xue, CaiLv Wei, YueHan Zhou, Kai Wang, YuWei Zhou, Chen Chen, Yuan Li, LongXiang Sheng, BingZheng Lu, Zhu Zhu, Wei Cai, XinPeng Ning, ShengLong Li, TianYu Qi, JiaKai Pi, SuiZhen Lin, GuangMei Yan, YiJun Huang*, and Wei Yin*, TRIOL Inhibits Rapid Intracellular Acidification and Cerebral Ischemic Injury: The Role of Glutamate in Neuronal Metabolic Reprogramming, ACS Chemical Neuroscience, 2022, 13 (14):2110-2121. 
6. Bingzheng Lu, Zhu Zhu, Longxiang Sheng, Yuan Li, Yang Yang, Yupin Chen, Dongdong Xue, Yuwei Zhou, Wei Cai, Chen Chen, Cailv Wei, Dong Xu, Min Yan, Suizhen Lin, Guangmei Yan, Wei Yin*, SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury, Oxidative Medicine and Cellular Longevity, 2020 Oct 23; 2020:2048210.
7. Sheng L, Lu B, Chen H, Du Y, Chen C, Cai W, Yang Y, Tian X, Huang Z, Chi W, Lin S, Yan G, Yin W.* Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway. Marine Drugs. 2019; 17(5):267.
8. Li Y, Lu B, Sheng L, Zhu Z, Sun H, Zhou Y, Yang Y, Xue D, Chen W, Tian X, Du Y, Yan M, Zhu W, Xing F, Li K, Lin S, Qiu P, Su X, Huang Y, Yan G*, Yin W.* , Hexokinase 2-dependent Hyperglycolysis Driving Microglial Activation Contributes to Ischemic Brain Injury.  Journal of  Neurochemistry. 2018,144, 186--200.
9. Yin W, Wang ZJ, Li QY, Lian JM, Zhou Y, Lu BZ, Jin LJ, Qiu PX, Zhang P, Zhu WB, Wen B, Huang YJ, Lin ZL, Qiu BT, Su XW, Yang HM, Zhang GJ, Yan GM, Zhou Q. Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper. Nature Communications, 2016 Oct 6;7:13107.
10. Li Y#, Yin W#, Wang X, Zhu W, Huang Y, Yan G*. Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway. Proc Natl Acad Sci U S A. 2007, Aug 14;104(33):13438-43.

科研项目

1. 国家自然科学基金面上项目，糖酵解酶己糖激酶2磷酸化SIRT6促进TNF-α释放：急性缺血性脑卒中损伤的非代谢新机制，No.82571509，2026-01至2029-12，49万；
2. 广东省自然科学基金面上项目，糖酵解酶HK2转录调节IL-6促进缺血性卒中炎性脑损伤，No. 2025A1515010730，2025-01 至 2027-12 ，10万；
3. 国家自然科学基金面上项目，己糖激酶2通过蛋白激酶活性调节星形胶质细胞外泌体生成参与急性缺血性脑损伤，No. 82071321，2021-01至2024-12，55万；
4. 国家自然科学基金面上项目，糖酵解关键酶HK2在缺血性脑卒中的神经元损伤新角色，No. 81773711，2018-01至2021-12，55万；
5. 广东省省级科技计划产业技术研究与开发专项，新型溶瘤病毒M1的一步法纯化工艺研究，No. 20160909，2016-08至2019/07，150万；
6. 广州市科技计划产学研协同创新重大专项（民生科技研究），新型小分子甾体预防急性低压缺氧脑损伤的临床前研究，No. 201704020103, 2017/05至2020/04，400万；
7. 国家自然科学基金面上项目，新型神经保护剂YC-6预防急性高原病的非人灵长类动物多组学研究，No. 81470162，2015/01至2016/12，30万；
8. 十一五科技部科技重大专项“重大新药创制”，直接溶栓药重组蛇毒纤溶酶II 的临床前研究（Ⅰ类新药）, No.2009ZX09102-217, 2010/01至2011/12，267万；
9. 国家自然科学基金青年基金，泛素相互作用蛋白KIAA0280的基因敲除及其对神经元凋亡信号通路的调控, No. 30700202, 2008/01至2010/12，17万。